Objective: To observe the feature of brain regional homogeneity (ReHo) in children with different degrees of obesity aged 7-15 years by resting state functional magnetic resonance imaging (rs-fMRI). Methods: Resting-state fMRI data were collected from 35 cases obesity children (OB), 20 cases obesity children with metabolic syndrome (MS), and 24 cases healthy children (HC). The data were analyzed,and ReHo differences among the three groups were compared. Then the correlation between the different brain regions and clinical data was analyzed. Results: Compared with HC group, the ReHo values of right fusiform gyrus and left inferior temporal gyrus in OB and MS groups were higher. The ReHo values of right medial superior frontal gyrus and left dorsolateral superior frontal gyrus decreased. Compared with OB group, the ReHo value of left dorsolateral superior frontal gyrus in MS group was lower. The ReHo values of left dorsolateral superior frontal gyrus were negatively correlated with ALT and AST transaminase(r=-0.3498,P=0.0089; r=-0.2944,P=0.0291).(all P<0.05). Conclusion: Obese children have abnormal functional activity in brain areas such as participating in feeding regulation and inhibitory control, and the abnormal activity in the left dorsolateral superior frontal gyrus is associated with the degree of obesity, and to provide imaging evidence for early intervention and treatment.