Objective: Whether the pregnancy would lead to the growth of pulmonary ground glass nodules (GGNs) was still unknown. This study aimed to observe whether the pregnancy would result in the growth of pulmonary GGNs or not based on a retrospective cohort in single center. Methods: Clinical and radiologic data of 44 gravidas who underwent pre- and post-pregnancy chest computed tomography (CT) scans due to pulmonary GGNs were retrospectively reviewed. The GGNs were divided into pure GGNs (pGGNs), heterogeneous GGNs (hGGNs) and part solid nodules. The size of the GGNs were determined as the largest diameter in the axial image. The time interval between pre- and post-pregnancy chest CT was defined as the observing interval. Nodule growth is defined as an increase of 2mm in the maximum diameter, an increase of 2mm in solid composition, or the appearance of new solid components. Results: There were 70 GGNs detected in 44gravidas, containing 66 pGGNs and 4 hGGNs. The size of 43 GGNs were less than 6mm in diameter, that of 22 GGNs were between 6.0 and 7.9mm, that of four GGNs were between 8.0 and 9.9mm, and that of one GGN was ≥10mm in diameter. No growth of pulmonary GGNs was observed at a median observing interval of 779 days (range 337 to 2795 days). Conclusions: Pregnancy is unlikely to cause the growth of pulmonary GGNs. The female patients in child-bearing period should not overly worry about the growth of GGNs if they planned to experience a pregnancy.