Abstract: Objective:To analyze the factors associated with prolonged postoperative hospital stay (≥30 days) after distal pancreatectomy (DP), identify independent risk factors, and provide a basis for optimizing perioperative management. Methods:A retrospective analysis was conducted on 1215 patients who underwent DP at a single center from January 2020 to June 2024. Based on postoperative hospital stay, patients were divided into two groups: ≥30 days (80 cases) and <30 days (1135 cases). Univariate analysis was used to compare differences in clinical characteristics between the two groups, and multivariate logistic regression was employed to identify independent risk factors. Results: Among the 1215 DP cases, 80 (6.6%) had a postoperative hospital stay ≥30 days. Univariate analysis revealed that gender, age, tumor type, modified Appleby procedure, combined organ resection, combined vascular resection, dissection of the Heidelberg triangle, as well as complications such as pancreatic fistula, delayed gastric emptying (DGE), postoperative bleeding, and chylous fistula were significantly associated with prolonged postoperative hospital stay (P < 0.05). Multivariate logistic regression analysis demonstrated that modified Appleby procedure (OR = 3.167, P = 0.007), combined organ resection (OR = 3.334, P < 0.001), postoperative bleeding (OR = 4.148, P = 0.025), DGE (OR = 10.482, P < 0.001), intra-abdominal infection (OR = 5.718, P < 0.001), chylous fistula (OR = 2.457, P = 0.022), sepsis (OR = 13.485, P < 0.001), and postoperative invasive interventions (OR = 6.045, P < 0.001) were independent risk factors for a hospital stay ≥30 days. Conclusion: Prolonged postoperative hospital stay (≥30 days) after distal pancreatectomy is associated with various perioperative factors. Developing individualized diagnostic and treatment strategies targeting high-risk factors and optimizing management can help reduce the length of hospital stay.