Huntington's disease (HD) is an autosomal dominant genetic disorder caused by the abnormal CAG repeat expansion in the huntingtin (HTT) gene. It is clinically characterized by choreiform movements, progressive cognitive impairments, and psychiatric symptoms, with no cure currently available. Although the researches based on traditional animal models and human tissues have revealed key pathological features such as mutant HTT protein aggregation and selective striatal neuron loss, significant limitations remain in understanding human-specific disease mechanisms. The development of human induced pluripotent stem cell (hiPSC) and brain organoid technologies has enabled the construction of human-specific HD models, providing revolutionary platforms for elucidating pathological mechanisms and developing novel therapeutic strategies. This review summarizes the developmental trajectories of both HD patient-derived iPSC (HD-iPSC) and human brain organoid technologies, highlights the research findings and significance of HD iPSC-derived cells, various brain organoids, and assembloids in HD research, and discusses the current challenges and future prospects of brain organoid applications.