Effects of Ethanol on Neuronal Activity of Rat Nucleus Accumbens Slices and It′s Interactions with Endogenous Opiate Peptides
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    Abstract:

    Objective The effects of ethanol (0.2 μmol/L) on the spontaneous electrical activity in the neurons of slice preparation of the nucleus accumbens septi (NAcc) was investigated. Methods Use extracellular recording.Results (1) In response to the application of ethanol into the superfusate for 10~15 min, spontaneous discharge rate (SDR) of 25 neurons was increased significantly, then, it was decreased (P<,0.01). This decreasing responses could be reversed by 0.2 μmol/L opiate antagonist naloxone (Nal), which suggests ethanol may exert some effects through interactions with endogenous opiate peptide systems of their receptors. (2) Following the application of DAGO, U-50 and D-PEN for 5~10 min respectively, the effect of ethanol might be reinforced. By statistical analysis of ANOVA, we conclude that the effect of DAGO, the selective μ opiate receptor agonist, is stronger than other two opiate receptor agonists. Conclusion (1) The spontaneous electrical activity of the NAcc neurons can be inhibited by ethanol. The effect of ethanol will be involved in endogenous opiate system. (2) It is possible that μ opiate receptor has the strongest effect on the ethanol inhibitory action.

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袁孝如,裴曙光,李晓璐.乙醇对伏核神经元电活动的影响及与内源性阿片肽的关系[J].南京医科大学学报(自然科学版英文版),2000,20(01).

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