vTo investigate the expression of laminin(LN) on normal endometrium, hyperplastic en dometrJum and endometrlal adenocarcinoma and; to study the relationship between LN's expression and endometrial adenocarcinoma. Methods LSAB immunohistoehemical method was used to study LNts expression on 16 normal, 12 hyperplastic and 27 adenocarcinoma endometrium cases. Results Laminin is widely expressd on epithelia basement membrane(EBM), epithelial/cancer cell(EC) and stromal cell (SC). Among normal, hyperplastie, adenocarcinoma endometrium, LN's expression on EBM (X2=13.06,P<0. 001), EC (X2= 17.82,P<0. 001), SC (X2=16.96,P <0. 01) and EC/SC (X2=27.49,P<0. 001) are significantly different. The LN's expression was compared with clinical and pathologic parameter of endometrial adenoeareinoma, and the clinical stages of endometrial adenocarcinoma compared with LNts expression on EBM (P<0. 05) and on SC (P<0. 01) ,and the pathologic grades of endame trial adenocarcinoma with LN's expression on SC (P<0.05), all those being different in statistics. Conclusion The LN's expression on epithelial/cancer cells and disapearane on epithelial basement membrane, stromal cells are related to endometrial carcinoma; It may be an important sign on the early stage of endometrlal adenocarcinoma.