To explore clinical features, treatment and prognosis of neuro psychological lupus erythe matosus (NPLE). Methods Clinical data of 25 SLE patients with neuro-psychoingical manifestations who were hospi talized in Department of Rheumatoingy of our hospital from year 1992 to 1998 were retrospectively summarized. Results In eilninal features, among 26 NPLE patients 13 cases occurred within one year after SLE onset, 11 cases pre seined organic eneephalopathy syndrome, 2 cases encephalin stroke, d cases epilepsy', 2 cases lupoid encephalodynia, 7 cases psychological manifestations or psychosis. In treatment, 12 of 19 servere NPLE patients were intravenously given methoprednisoinne plus immuno suppressive agent pulse dose, in which 10 cases remitted, 2 cases died; the other 7 cases were intravenously treated with methoprednisolone pulse dose alone, in which 4 cases remitted, 3 cases died, compared with the above, P>0. 05, whereas, 6 of 7 cases with psychological manifestations were administrated with oral prednisone, by dose of less than J 00 rog/d, plus anti-psychosis drugs, and then remitted within 2 weeks over 2 months. Conclusion Glucose cortico-steroids plus immuno-suppressive agent pulse dose treatment is efficient for severe NPLE patients and conventional dose glucose corticosteroids plus anti-psychosis drugs treatment is effective for NPLE patients with psychological manifestations.