Objective： To explore the effects of dipeptide-supplemented total prenteral nutrition（TPN）， traditional TPN on the function change of liver graft after orthotopic liver transplantation. Methods：Thirty-five patients were randomly divided into three groups： diet group（receiving common diet）， traditional group（receiving TPN without Ala-Gln）， dipeptide group（receiving TPN and Ala-Gln）. Patients in traditional group and dipeptide group received isocaloric［104.6 kJ／（kg·d）］ and isonitrogenous［0.16 g／（kg·d）］ on the second day to the eighth day after transplantation. Liver function-related index was measured on the second day and the ninth day after liver transplantation respectively. Results： Aspartate aminotransferase（AST） of dipeptide group decreased more significantly compared with diet and traditional group（P < 0.01，P < 0.05）；Apolipoprotein B（APOB） of traditional group and dipeptide group increased more significantly compared with diet group（P < 0.01）；Cholinesterase（CHE） of dipeptide group increased more significantly compared with diet and traditional group（P < 0.01）on the ninth day after OLT. Conclusion：TPN improves the function and recovery of ischemia reperfusion injury of graft. Ala-Gln increases the effects of TPN.