Objective: To investigate the effects of grape polyphenols（GP） on lipid metabolism disorders in rats. Methods: Forty male Wistar rats were divided into 4 groups randomly. The rats in control group were fed with basic diet, and the rats in model groups were fed with high fat diet for 30 days. The model groups rats were simultaneously fed with at 0, 40, 120 mg／kg. of Gp for 30 days, respectively. The serum samples of all animals were collected and used for biochemical analysis. Results: The body weight growth curves of animals among groups were similar. The serum levels of TC, TG, LDL-C and VLDL-C were significantly higher in model groups than those in control group. The levels of serum HDL-C, HDL2-C were obviously lower in model groups than those in control group. In GP-treated groups, however, the serum levels of TG，TC，VLDL-C and LDL-C were obviously lower than those in high fat diet animals（P < 0.05 or P < 0.01）, but still higher than those in control group. Compared to high fat diet group, the serum level of HDL2-C was increased and HDL3-C level was decreased. GP-treated groups. Conclusion: GP might play an important role in modulating blood lipid.