Objective: To evaluate the effects of parenteral infusion of fructose or glucose on metabolic changes in post-operative patients. Methods:A polycentric, double blind and randomized clinical trial was conducted in 124 post-operative patients. The patients were divided in two groups, and fructose solution（10%，750 ml） or glucose solution（10%，750 ml） were infused intravenously affer operation. Serum glucose and insulin level were monitored to evaluate the metabolic responses to different parenteral protocols. Results：Infusion of glucose increased in insulin activity, however fructose infusion had no such effects. Conclusion：Parenteral fructose, has a significantly less adverse impact than glucose on the glucose balance in the post-operative state. The benefits of fructose-specific metabolic effects suggest that fructose is an important nutrient that contributes to metabolic stabilization, especially in the post-operation phase and in trauma patients.