Objective：To evaluate the clinical effects of interventional treatment for lower extremity deep venous thrombosis （LEDVT）. Methods:In 576 cases of LEDVT, 226 cases were implanted with inferior vena cava filters, and the thrombosis of 59 cases were aspirated by catheters. The mechanical thrombectomy devices were used to manage acute LEDVT in 119 cases. PTA was performed in 92 cases and stents were placed into iliac veins in 71 cases. Two to six methods were selected for each case depending on the history, symptom and angiography. The patients were followed up for 6 to 36 months. Results: Out of 576 cases, 170 cases presented with excellent efficacy, 269 cases with good efficacy, 126 cases with mild efficacy and 11 cases with no change. Mean hospital stays was 9.5 days. 89 cases had 6 months follow-up data including 34 excellent（38.2%）, 45 good（50.6%）, 4 mild（4.5%）, and 6 no changes （6.7%）. Conclusion: Interventional treatment of LEDVT is effective, it can shorten the course of LEDVT.