Objective:To assess the association of HLA-DRB1*13 allele with chronic hepatitis B（CHB） in Chinese Han population． Methods：A comprehensive search for articles from 1998 to 2006 was conducted from CBMdisc, VIP database and Medline database. Six epidemiological case-control studies on the association between HLA-DRB1*13 allele and CHB were collected and analyzed using RevMan 4.2 software. Results：A total of 335 CHB cases and 659 healthy controls from these 6 studies were involved．There was no evidence showing a publication bias after Egger’s linear regression analysis. The meta-analysis results showed that HLA-DRB1*13 allele might be a protective factor against CHB, and the pooled odds ratio（OR） values was 0.40（95％CI：0.21-0.79，P = 0.008）. Conclusion:By meta-analysis, it is suggested that HLA-DRB1*13 allele might be associated with the resistance to CHB in Chinese Han population．