Inhibitory effects of troglitazone on proliferation of papillary thyroid carcinoma cell
DOI:
CSTR:
Author:
Affiliation:

Clc Number:

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    Objective:To investigate the effects of troglitazone on growth of thyroid papillary carcinoma cell line IHH-4 and the mechanisms possibly involved. Methods:Papillary thyroid carcinoma cell line IHH-4 was incubated with different concentrations of troglitazone and observed at different times, and the cell viabilities were measured through dimethylthiazol-diphenyltetrazolium bromide(MTT) assay. The cell cycles of the stimulated cells were analyzed by flow cytometer, and the expression of p27 mRNA was evaluated by semi-quantitative RT-PCR. Results:Troglitazone inhibited the proliferation of thyroid carcinoma cells in a dose-dependent and time-dependent manner(P < 0.05). After treated by troglitazone,the proportion of cells in GO/G1 phase increased significantly(P < 0.05), and p27 mRNA expression was up-regulated. Conclusion:Troglitazone inhibits the growth of papillary thyroid carcinoma cells by arresting the G1/S phase transition, so troglitazone could be a choice for the treatment of the aggressive thyroid carcinoma.

    Reference
    Related
    Cited by
Get Citation

侯大卫,沈美萍,刘翠萍.曲格列酮抑制甲状腺乳头状癌细胞生长的体外试验[J].南京医科大学学报(自然科学版英文版),2007,(3):249-252.

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:October 08,2006
  • Revised:
  • Adopted:
  • Online:
  • Published:
Article QR Code