Objective：To investigate the effects of high glucose on the expression of ICAM-1mRNA in human mesangial cells and the intervention of tea polyphenols（TPs）. Methods：Human mesangial cells were cultured in DMEM media containing high glucose with or without TPs for 0，12，36 hours，respectively. The mRNA and protein expression of ICAM-1 were measured by RT-PCR and immunocytochemistry. Results：The mRNA and protein expression of ICAM-1 of the cells increased significantly in high glucose medium（P < 0.05）. However，TPs inhibited the expression（P < 0.05）. Conclusion：High glucose contributes to the increase of ICAM-1 expression in human mesangial cells. TPs can reduce high glucose-induced expression of ICAM-1.