Effects of tea polyphenols on high glucose-induced expression of ICAM-1 mRNA in human mesangial cells
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    Abstract:

    Objective:To investigate the effects of high glucose on the expression of ICAM-1mRNA in human mesangial cells and the intervention of tea polyphenols(TPs). Methods:Human mesangial cells were cultured in DMEM media containing high glucose with or without TPs for 0,12,36 hours,respectively. The mRNA and protein expression of ICAM-1 were measured by RT-PCR and immunocytochemistry. Results:The mRNA and protein expression of ICAM-1 of the cells increased significantly in high glucose medium(P < 0.05). However,TPs inhibited the expression(P < 0.05). Conclusion:High glucose contributes to the increase of ICAM-1 expression in human mesangial cells. TPs can reduce high glucose-induced expression of ICAM-1.

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李 群,李海浪,邓 红,张有为,陈露露,刘必成.茶多酚对高糖时人肾小球系膜细胞细胞间黏附分子1表达的影响[J].南京医科大学学报(自然科学版英文版),2007,(4):295-298.

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  • Received:September 24,2006
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