Objective：To study the clinical correlated factors of renal damage in Henoch-Schonlein purpura（HSP）. Methods：Two hundred and six cases with HSP treated from May 1，1999 to May 31，2004 were retrospectively studied. Based on the urinary routin examination, the patients were divided into two groups, HSP without（128 cases） or with renal damage （78 cases）. In addition, based on the duration of urinary abnormality, the group of HSP with renal damage was further divided into two groups, HSP with passing（<1 week, 40 cases） or persistent（>1 week, 38 cases）urinary abnormality. Blood routin, urinary routin, biochemical examination, serum immunoglobulin, C3, C4, CIC, ASO, lymphocyte subpopulations were detected. Statistical analyses were performed using t test or chi square, a multivariate analysis（Binary Logistic Regression） to evaluate the potential factors of renal involvement. Results：In HSP group with renal damage, duration of the purpura, spread of the purpura, abdominal pain, hemorrhage of digestive tract, neutral cell percent, lymphocyte cell percent, serum total protein, serum albumin, serum urea nitrogen, serum total cholesterol and IgG were significantly different from those in HSP group without renal damage（P < 0.05）. In HSP with passing urinary abnormality, age, duration of the purpura, urinary routin examination, 24-hour urinary protein excretion, white blood cell count, serum total protein, serum albumin, IgG were significantly different from those in HSP wih persistent urinary abnormality（P < 0.05）. Neutral cell percent, serum albumin, serum total cholesterol were found to be independent risk factors for renal involvement, with a partial regression coefficient of 0.037（P = 0.042），-0.154（P = 0.003），0.916（P = 0.002） respectively. Conclusion：Increased neutral cell percent and serum cholesterol, decreased serum albumin are risk factors for renal involvement in HSP. In addition, duration of purpura, hematuria with proteinuria, heavy proteinuria, increase of age and neutral cell percent, decrease of serum total protein , serum albumin and IgG may be related with duration of renal damage.