objective：To evaluate the experience of video-assisted thoracoscopic surgery（VATS）for bilateral bullous lung disease in the one-stage operation. Methods：Ｏne-stage operation VATS procedures were performed on 53 patients with bilateral ballous lung disease. 11 patients were operated with video-assisted minithoracotomy（VAMT）. Results：All patients were cured． The mean duration of chest drainage after surgery was 4.6 days. Postoperative complications occurred in 13 cases，including pulmonary edema，pneumothorax again respiratory failure ａｎｄ ｓｏ ｏｎ. The mean postoperative hospital stay was 14.6 days. The patients were followed up 1 month to 5 years. Conclusion：VATS is an effective and preferred method for bilateral bullous lung disease. Advantages of VATS over conventional open techniques for bilateral bullous lung disease include shorter hospital stays, less postoperative pain, and earlier return to work.