Study of the correlation between the expression of TGF-β1mRNA and lymphatic metastases,survival rate with gastric cancer
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    Abstract:

    Objective:To study the correlation between the expression of TGF-β1mRNA in gastric cancer tissues and the tumor lymph node metastasis and survival rate after operation,the expression can be used to estimate progression and prognosis. Methods:Using in situ hybridization method,66 specimens and 10 normal tissue specimens(controls) were tested for the expression of TGF-β1mRNA. The survival rate after operation was investigated also. The correlation between TGF-β1mRNA and survival rate was analyzed. Results:The gastric cancer in 66 specimens died in 5 year was 88.46%(23/26). The positive expression rate of TGF-β1mRNA in gastric cancer was 86.36%(57/66),while it was 10.00%(1/10) in controls,indicating significant difference between them(P < 0.01). The negative and lower positive expression of TGF-β1mRNA in those who died after 5 years was 47.50%(19/40),in those who died in 5 year was 52.50%(21/40),indicating significant difference between them(P < 0.05). The middle and strong positive expression of TGF-β1mRNA in those who died after 5 years was 11.54%(3/26), in those who died in 5 year was 88.46%(23/26). The positive expression of TGF-β1mRNA in those who have no tumor lymph node metastasis was 75.00%(24/32),while it was 97.06%(33/34) in those who have tumor lymph node metastasis,indicating significant difference between them(P < 0.05). There was positive correlation between the higher expression of TGF-β1mRNA and the worse prognosis and rapid progression of gastric cancer. Conclusion:TGF-β1 can stimulate gastric cancer grow and become more aggressive and the tumor lymph metastasis. The detection of TGF-β1mRNA can be used to estimate gastric cancer patients,progression and prognosis.

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丁国芳,方海飞,徐银峰,郁迪.TGF-β1mRNA在胃癌中表达及其与淋巴转移、生存率的相关性研究[J].南京医科大学学报(自然科学版英文版),2007,(6):573-575578.

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  • Received:September 09,2006
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