Objective:To evaluate the effect of remifentanil pretreatment on propofol injection pain. Methods:A double blind and randomized study of 150 adults undergoing general anesthesia(GA) for elective surgery was conducted. All patients were randomly assigned to one of the three groups: groupⅠ(n = 50) received 10 ml of remifentanil 50 -滋g pretreatment, groupⅡ(n = 50) received 2% lidocaine 40 mg pretreatment, and group Ⅲ received normal saline pretreatment followed 30 s later by propofol 2 mg/kg. During induction of GA, the pain response was recorded. Hemodynamic data were also recorded. Results:The incidence and intensity of injection pain was significantly less in the group ⅠandⅡ than those in the group Ⅲ(P < 0.05), and the hemodynamic data were not significantly changed(P > 0.05). Conclusion:Propofol-induced pain can be reduced by remifentanil pretreatment.
黄亚辉,谈珊柏,梁萍,刘存明.预注雷米芬太尼缓解丙泊酚乳剂注射痛的临床观察[J].南京医科大学学报(自然科学版英文版),2007,(6):606-608.