Objective:To evaluate the diagnosis of CT perfusion in chronic obstructive pulmonary disease(COPD). Methods:Twenty volunteers and 20 COPD sufferers underwent MSCT perfusion imaging. Cine scan slice with thickness 5 mm/1i were processed by 8-row detector spiral CT. Scan time was 0.5 s per circle, delay of time 5 s, and overall scan time was 45 s. Omnipaque(300 mg/ml) was administered at a rate of 4 ml/s from forearm superficial vein for a total of 60 ml by high pressure injector. The data were transferred to a workstation and analyzed by a CT perfusion 3 software, automatically generating a time-density curve and pseudo-color map. Interest district blood flow, blood volume, mean transit time and permeability surface were measured. Results:Time-density curve of COPD patients was flatter than that of the volunteers, and peak height was obviously lower. The COPD sufferers’ blood flow, blood volume and permeability surface were obviously lower than the volunteers’, which had statistical significance(P < 0.05). Conclusion:MSCT perfusion is helpful to the diagnosis of COPD.