Objective:To detect the effect of PDTC,the selective inhibitor of NF-κB,on the growth and apoptosis of human gastric carcinoma cell SGC-7901,to analyze the expression of Livin and Caspase-3 of cell SGC-7901treated by PDTC,and to explore the mechanism of PDTC in induction of tumor cell-蒺s apoptosis. Methods:After the treatment with PDTC on human gastric carcinoma cell SGC-7901,MTT assay was used to observe the growth inhibition of cell SGC-7901.The cell apoptosis was assessed by flow cytometry (FCM). The mRNA and protein expressions of Livin and Caspase-3 were detected by real time PCR and Western blot assay,respectively. Results:When PDTC was given,growth inhibition and elevated apoptosis of SGC-7901 cells were detected,which was showed in a dose- and time- dependent manner. PDTC also down-regulated the level of mRNA and protein expression of Livin,and elevated the mRNA and protein expression of Capase-3. Conclusion:PDTC can induce apoptosis of human gastric carcinoma cell SGC-7901 cells,which may be performed by down-regulating of Livin and up-regulating of Caspase-3 expression.