The effects of lamotrigine and topiramate on electroencephalogram and the expression of Bcl-2 and Bax of the epilepitic rats
DOI:
Author:
  • Article
  • | |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • | |
  • Comments
    Abstract:

    Objective:To explore the effect of lamotrigine(LTG) and topiramate(TPM) on the behaviors and electroencephalogram (EEG) of epileptic rats induced by penicillin,and to explore the protection of LTG and TPM for the neurons of hippocampus. Methods:The seizures were observed in the group of epileptic rats induced by penicillin, the group of the rat given LTG, the group of the rat given TPM,the group of the rat given Sodium Valproate, and EEG was recorded in these groups. Immunohistochemical staining was used to observe the expression of Bcl-2 and Bax. Results:The epileptiform discharges decreased in the group of the rat given LTG and the group of the rat given Sodium Valproate, compared the group of the rat given LTG and TPM with the group of the rat given Sodium Valproate. We found that the latencies and durations of seizure between the group of the rat given LTG and the group of the rat given Sodium Valproate had significant difference(P < 0.01). Compared with the epileptic group induced by penicillin,Bcl-2 positive cells increased and Bax positive cells decreased in the group of the rat given LTG and the group of the rat given odium Valproate(P < 0.01). Compared with the group of the rat given Sodium Valproate,Bcl-2 positive cells in the group of the rats given LTG group and in the group of the rats given TPM were increased(P < 0.01). Conclusion:LTG and TPM was better than the Sodium Valproate in the anti-epileptic effects. LTG and TPM can protect hippocampal neuron in the epileptic rats induced by penicillin.

    Reference
    Related
    Cited by
Get Citation

许 虹,孙超艳,杨 佳,冯忠堂,徐国卫.拉莫三嗪?托吡酯对癫疒大鼠的脑电图及Bcl-2?Bax表达的影响[J].南京医科大学学报(自然科学版英文版),2007,(8):856-859.

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:November 20,2006
Article QR Code