Objective:To investigate the current status of acute poisoning in children in Nanjing city and analysis on its variation characterization and possible reason distribution. Methods:Local pediatric patients hospitalized for acute poisoning at Nanjing Children’s Hospital over a 3 year period(2004~2006) were evaluated retrospectively. Special attention was given to poisoning in relation to type, distribution in age and season, and general information as well. Results:The acute poisoning in children presented at special age. The frequency of children before school age was 93%, especially at the age of 2 years(32.5%). Drugs were the most common agent of poisoning(66.5%) and mostly were adult drugs such as drugs to depress blood-pressure(19.1%). The frequency of acute poisoning was higher in summer and autumn than that in spring and winter. The agents of poisoning between four seasons were different. Drug, pesticide, househood chemicals and food was the most agent in four seasons, respectively. Conclusion:The poisoning induced by drug misusage in children is the most frequent type of poisoning in Nanjing. Therefore, the standardized management and usage for drug should be strengthened in order to reduce the local occurrence of acute poisoning in children.