The effects of GCP-02,a PPARα/γ dual agonist,on glucose utilization,pre-adipocyte diff-erentiation and cell viability in vitro
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    Abstract:

    Objective:To investigate the effects of GCP-02,a PPARα/γ dual agonist,on glucose utilization,pre-adipocyte differe-ntiation and cell viability in cultured cells. Methods:GCP-02 was tested for its effects on glucose transportation and consumption in HepG2 cells,on adipocyte differentiation in 3T3-L1 cells,respectively. Viability of HepG2 and WB-F344 cells was also investigated. Results:Viability of WB-F344 cells originated from rat was inhibited while that of HepG2 was not influenced by GCP-02 at the concentration of 10-5 mol/L. GCP-02 increased glucose consumption but not glucose transportation in HepG2 cells. It promoted oil production at the concentrations with no influence on cell viability in 3T3-L1 cells. Conclusion:GCP-02 increased glucose consumption in HepG2 cells,promoted 3T3-L1 pre-adipocyte differentiation,suppressed viability in WB-F344 cells.

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王振基,刘 泉,邹晨辉,申竹芳. PPARα/γ双激动剂GCP-02对细胞葡萄糖利用?前脂肪细胞分化和细胞活力的影响[J].南京医科大学学报(自然科学版英文版),2007,(9):916-919980.

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  • Received:June 17,2007
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