Objective:To compare the efficacy and the safety of conjugated estrogen(CE) in the treatment of menopausal with conjugated equine estrogen(Premarin). Methods:According to the standards ,a total of 60 patients were randomly divided into 2 groups:CE group and Premarin group,a period of 28 days,and from 15 to 28 days plus medroxyprogesterone(MPA) 4 mg Daily.Treatment lasted for 3 periods. This randomly publicly parallel was adopted to compare the hot flashes symptom scores,serum level of estradiol,Kupperman measurement Index and serum lipid. Results:The scores of menopausal symptom,hot flash scores and the serum level of estradiol ascent. TG-HDL-C ascented and LDL-C were reduced after treatment with CE or Premarin(P < 0.001),No significant differences were discovered between the two groups through equivalence margin(P > 0.05). There are no significant differences between the two groups on side effect(P > 0.05). Conclusion:CE is safe and effective in treatment of menopausal symptoms.