Objective:To investigate the relationship between inflammation factors and peripheral vascular disease(PVD) in Type 2 diabetes(T2DM) patients. Method:The level of inflammation factors including hsCRP,IL-6,TNF--琢 were compared between PVD patients(ABI < 0.9) and N-PVD patients(ABI≥0.9), and the differences in body mass index (BMI),blood pressure (BP),serum glucose,HbA1c,and history were also observed. Result:The hsCRP level in PVD was significantly higher than that of N-PVD(0.61 ± 0.72 vs 0.12 ± 0.93,P < 0.001). The risk of PVD obviously increased when hsCRP was higher than 0.83 mg/L. The patients with cardiocerebrovascular disease had higher level in IL-6 than those who didn’t have such disease in PVD group. The PVD patients were older,while with higher level of fibrinogen ,more prevalent of stroke and lower diastolic blood pressure than that of the N-PVD ones. Conclusion:Inflammation factors had the similar clinical importance for the onset and progress of PVD pateints with cardiocerebrovascular disease. The existence of PVD should be paid affention to when the level of hsCRP was higher than 0.83 mg/L.Perhapse IL-6 was an alarm for initial atherosclerosis. Aging was one of the major risk factors of PVD in T2DM patients. There were unclear relationships between PVD and things such as fibrinogen,hypertension,and cerebrovascular disease.