Objective：To estimate the qualification, time, and technique of ventilator dependent patients weaning from the ventilation with the end-stage lung disease after lung transplant. Methods：A retrospective review of patient records and computerized database was performed. From September 2002 to June 2006, there were 6 cases of ventilator dependent recipients received lung transplant. Results：The 6 patiemts were weaned from the ventilator successfully in average 13.5d after lung transplatation. The follow-up time after operation was 1~4 years. The average life span was（２１.33 ± 3.48）month. Conclusion：The infection control，airway management, nutrition support, PGE1 utilizing, respiratory muscles exercise, and mental nursing are the important issue for weaning from the ventilator.