Objective：To explore the surgical technics，early clinical results and the key point of perioperative management of single lung transplant in treating end-stage lung disease. Methods：From June，2006 to January，2007，4 cases of end-stage lung disease patients received right single lung transplantation. The first and the second case received the operation in the same day. Results：The first case was infected with bacillus pyocyaneus and amotile bacillus after operation，which resisted to almost all kinds of antibiotics. This case died of serious pulmonary infection 33 days postoperatively. The other 3 cases were discharged in 27 days，51 days and 60 days after operation respectively and all were in follow-up. The patients’ life quality, SaO2 and FEV1 improved significantly. Conclusion：Single lung transplantation is an effective treatment for end-stage lung disease. But the morbidity and mortality caused by infection and acute rejection after operation are very high. It was very important to enhance the perioperative management of lung transplantation.