Objective:To make a comparative analysis of early and mid-term outcomes in two different age groups receiving off-pump coronary artery bypass grafting(OPCAB). Methods:From January,2005 to May,2007,145 consecutive isolated patients undergoing OPCAB were divided into two groups according to their age:the relatively elder group(≥70 years),n = 68 and the relatively younger group(<70 years),n = 77. Early and mid-term outcomes were comparatively analyzed with the combined follow-up of letter,telephone and out-patient clinic re-examination. Results:There were no hospital deaths in each group. There was no significant difference in postoperative average ICU stay and hospital stay time,major cardiac events rate in two groups. But compared with the relatively younger group,the average intubation time,blood transfusion and atrial fibrilation incidence were remarkably higher in the relatively elder group(P = 0.001). Conclusion:OPCAB provides satisfactory early and mid-term clinical outcomes for the elderly as well as younger patients.