Objective:To study the clinical pathologic significance of tumor budding in colorectal carcinoma. Methods:The tumor budding of 83 cases of colorectal carcinoma were detected by HE staining and EnVision immunohistochemical staining. Results: Tumor budding was found in 46 cases of colorectal carcinoma(55.4%). Tumor budding was more frequently observed in colorectal carcinoma with lymph node metastasis than in those without lymph node metastasis(P < 0.01). The incident of tumor budding was higher in colorectal carcinoma with lymphatic involvement than in those without lymphatic involvement(P < 0.01). Among pTNM staging,the detection rate of tumor budding in colorectal carcinoma with Ⅲ stage was higher than those with Ⅱ stage(P < 0.01). Tumor budding were not associated with sex,age,tumor size,site,differentiation and venous invasion(P > 0.05). Conclusion:Tumor budding was a potential pathological marker suggesting aggressive or invasive growth of colorectal carcinoma. The detection rates of tumor budding was improved by CKpan immunohistochemistry.