Objective:To observe the influence of Somatostation(SST) or Vasoactive Intestinal Peptides(VIP) on intestinal lymphocytes homing to Gut-associated lymphoid tissues(GALT) and to primarily explore its possible mechanisms. Methods:Intestinal lymphoctes were collected from rats’ intestinal lymphatics. After incubated with VIP or SST,they were labeled with 51Cr and then infused into veins of rats. 51Cr-lymphocytes in GALT were countered with γ counter 1 h later. And then the mRNA expression of SSTR-1~5,VIPR-1~2 on the lymphocyes were measured by RT-PCR. Results:The distribution of 51Cr-lymphocytes treated with VIP or SST in Peyer’s Patches were significantly less than that in control group, and no significant changes between diffusive lymphatic tissue of small intestinal and control group were observed. The rats’ intestinal lymphocytes apparently expressed the mRNA of SSTR-3 and VIPR-2. Conclusion:Under physical state,VIP or SST suppresses intestinal lymphocytes homing to Peyer’ patches,which may be directly mediated by SSTR-3 or VIPR-2 on the intestine lymphocytes.