Objective:To establish the method of making chronic ischemic myocardial models in swines by full-endoscopy. Methods:The myocardial ischemia was established by gradual occlusion of the left circumflex coronary artery(LCX) with an Ameroid constrictor. An Ameroid constrictor was implanted around LCX by full endoscopy. Selective coronary angiography were performed postoperatively to evaluate the degree of stenosis and collateral circulation. Results:Chronic ischemic myocardial models were successfully constructed in 20 swines by full-endoscopy. Six weeks later,coronary angiography revealed that the total occlusion and partial stenosis(>85%)of the LCX in 7 and 13 swines separatively. The coronary collateral circulation was obviously formed. Conclusion:The full-endoscopic operation could construct coronary artery occlusion animal models with less injury than thoracic surgery.
陈仕林,朱成楚,唐礼江,包卫光,周文娟,王东进.经胸腔镜猪慢性心肌缺血模型的制作[J].南京医科大学学报(自然科学版英文版),2008,28(3):338-340.