Objective:To investigate the epidemiological characteristics of hepatitis E virus(HEV) infection in rural area of Jiangsu provine and explore correlated effect factors. Methods:A cross-section and a follow-up seroepidemiologic study of HEV infection were conducted. Anti-HEV IgG and IgM were tested by commercial ELISA kits,and the RT-PCR method was applied to obtain the sequence of HEV from subclinical infection cases. Meanwhile correlated effect factors were studied. Results:The cross-sectional seroepidemiologic study showed that the anti-HEV IgG prevalence were 52% in the general population. The seropositivity rates of anti-HEV-IgG was highter in male than in female(P < 0.001),and the antibodies increased with age. Based on results from the follow-up study,the positive and negative seroconversion rate were 11.6% and 5.8% respectively. Overall,the positive seroconversion rate was higher in people more than 20 years old than in those less than 20 years,but the negative seroconversion rate of 0~9 year age group was higher than that of the older age groups. Both genotypeⅠ and genotype Ⅳ HEV were isolated from subclinical infection. Man,advancing age and breeding swine were risk factors in the infections of HEV. Conclusion:The prevalence of hepatitis E virus infection in this district was higher than any other districts reported in China. Genotype Ⅰ and genotype Ⅳ HEV were isolated from subclinical infection. Besides gender and age,breeding swine were effect factors in the infections of HEV.
张雪峰,张〓军,刘社兰,田〓华,许〓可,孟繁岳,夏宁邵,朱凤才.江苏省农村地区自然人群戊型肝炎感染状况的研究[J].南京医科大学学报(自然科学版英文版),2008,28(3):360-363.