Objective:To explore the effects of the prevaccination antibody titer on the positive rate of antibody,and to find the sensitive herd of influenza vaccination for providing the scientific basis for the flu prevention. Methods:Duplicates entire group random sampling method were used. The antibody was abstracted from natural populations in Changzhou,Yancheng,Nanjing,Huaian,Suqian and Yangzhou. The antibody of influenza was measured by the hemagglutination inhibition test and the positive rate of antibody. Results:The positive rate of subtype A3 and type B were different in ages. The positive rate of subtype A3 was higher in infant and pre-school children,while that of type B was lower than other years-old people. Along with the increasing of pre-immune antibody titer,the positive rate gradually reduced in the person who had protection from influenza. Youden’s index found that the threshold of subtype A1,subtype A3 and type B was 1 ∶ 160,1 ∶ 160 and 1 ∶ 80 respectively. Conclusion:When pre-immune antibody titer of subtype A1,subtype A3 and type B exceeded 1 ∶ 160,1 ∶ 160 and 1 ∶ 80,influenza vaccination couldn’t achieve the anticipated immune effect.
严〓睿,朱凤才.流感免疫前抗体水平对疫苗免疫效果的影响[J].南京医科大学学报(自然科学版英文版),2008,28(3):364-367.