Objective:To evaluate the relationship between the presentation of typical symptoms of focal nodular hyperplasia(FNH) by means of dynamic contrast-enhanced ultrasonography(CEUS) and the lesion size. Methods:26 cases with pathologically proven FNH were examined by GE-LOGIQ9 and Technos MPX DU8 color Doppler ultrasound system with contrast-enhanced ultrasonography software and Sonovue Meanwhile,the engorged process and type,the enhanced extent of the hepaticparenchyma and lesion focus were recorded. Results:In lesions with diameter≥3 cm(n = 15), the spoke-wheel pattern of vessels enhancing early in arterial phase was seen in 14 cases(93.3%). The Central scar was observed in 13(86.6%) cases in late phase. Conclusion:The contrast-enhanced ultrasonography might be an important diagnostic method for FNH with diameter ≥3 cm, which has the typical spoke-wheel pattern and central scar symptoms in CEUS.