Objective:To study the relationship between insulin resistance and NAFLD. Methods:The age,BMI,WHR,TRIG,TC,and insulin sensitive index(ISI) were studied in NAFLD group and the control group. Results:The BMI,WHR,TRIG were higher in NAFLD than in the control,while the ISI was lower in NAFLD than in the control. The Logistic analysis show that WHR and ISI are important factors in the pathogenesis of NAFLD. Conclusion:WHR and ISI are the independent influential factors in the pathogenesis of NAFLD.