Objective:To investigate the protective effect of Edaravone against hepatic ischemia-reperfusion injury in rat and clarify its possible mechanism. Methods:The model of 70% hepatic ischemia-reperfusion was established in SD male rat. Twenty four healthy rats were randomly divided into 3 groups,S: sham operation group(n = 8),IR:ischemia-reperfusion group(n = 8),ED:Edaravone treatment group(n = 8). After 2 hours of reperfusion,the enzyme levels in serum were examined including ALT and AST. The SOD,MDA and MPO in liver tissues were measured. The expression of NF-κB in liver cell was determined in immunohistochemistry, and histologic changes was observed in HE staining. Results:After ischemia-reperfusion,the levels of ALT,AST,MDA, the activity of MPO and NF-κB expression in IR group was significantly higher than those in S group. The injury of liver tissue in IR group was more obviously,but the activity of SOD was decreased. After treatment of Edaravone,the all above abnormal parameters were retrieved remarkably(P < 0.01). Conclusion:This study suggests that Edaravone has a protective effect on liver against ischemia-reperfusion injury in rat. The mechanism of protection may be related to its scavenging of radical,inhibiting of lipid peroxidation,and suppressing of NF-κB activation.