Objective:To investigate the association of loci 1587 polymorphisms of ATP binding cassette transporter 1 gene with coronary heart disease(CHD) and lipoprotein levels. Methods:Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 260 patients with CHD and 248 control subjects. Results:Three genotypes were shown in the present study. RR, RK and KK genotypes accounted for 76.97%,18.11% and 4.92%, respectively. Neither the allele frequencies nor genotypes showed significant difference between patients with CHD and control subjects(P > 0.05). The HDL-C levels was lower in K allele carriers than in non-K allele carriers. Conclusion:The genotypes of ABCA1 R1587K polymorphism were associated with the plasma levels of HDL-C. The HDL-C level of K allele carriers was remarkably lower than that in non-K allele carriers. However,there was no significant association of ABCA1 R1587K polymorphism with CHD.