Objective:To study the therapeutical effects of salvianolate on acute myocardial infarction(AMI) in swines. Methods:Twenty-one young swines were divided into high-dose,low-dose and control group randomly(n = 7,each group). AMI models were made by deligating anterior descending branch as myocardial infarction model. Salvianolate 400 mg + 5% GS 250ml or salvianolate 200 mg + 5%GS 250 ml was injected into swines through the vein once dayly immediately after coronary artery deligated for 7 days in high-dose,low-dose and control group, respectively. Four weeks after operation,coronary bypass circuit and LVEF were evaluated by coronary arteriongraphy,immunohistochemistry and gated myocardial perfusion imaging, respectively. Results:①Coronary arteriongraphy:The circulation of infarction region of therapic group was better than that of control group obviously,especially in high dose group; ②Gated myocardial perfusion imaging:LVEF in two therapic groups was higher than that in control group;③Immunohistochemistry:capillary density of therapic group was significantly higher than that of control group,but there were no significant differences between high-dose and low-dose groups. Similarly,function density of treatment groups also significantly higher than that of control group, which also was higher in the high-dose group than that in low-dose group. Conclusion:Therapeutical effect of salvianolate on acute myocardial infarction(AMI) in swines through the vein is significant. Salvianolate therapy can improve heart function and promote blood vessel regeneration,promote formn of collateral blood vessel.