Objective:To study the expressions of CTGF and VEGF and detect their clinical value and correlation in oesophageal squamous cell carcinoma tissues and paracancerous tissues. Methods:SP immunohistochemical method was used for the assayes of CTGF and VEGF on the routinely paraffin-embedded sections of surgical operated specimens of 49 cases with oesophageal squamous cell carcinoma and 41 ones with paracancerous tissues. Results:the positive rate of CTGF and the score were significantly lower in cancer tissues than those in paracancerous tissues(46.9% vs 82.9%,P < 0.05;2.21 ± 1.14 vs 4.45 ± 1.37,P < 0.01),but those of VEGF were opposite(79.6% vs 19.5%,P < 0.01;3.69 ± 1.46 vs 1.12 ± 0.74,P < 0.01). The positive rates and scores of CTGF were significantly higher in the cases without metastasis of lymphnode and in clinical stage T1 than those in the ones with metastasis of lymphnode and in clinical stage T3(P < 0.01). The positive rates and scores of VEGF were significantly lower in the cases without metastasis of lymphnode, in clinical stage T1 and histological grade Ⅰ than in those with metastasis of lymphnode,in clinical stage T3 and histological grade Ⅲ(P < 0.01). The close negative correlation was found between the score of CTGF and VEGF. Conclusion:The expressions of CTGF and VEGF migh be important biological markers in reflecting the progression,biological behaviors,metastatic potential and prognosis of oesophageal squamous cell carcinoma.