Objective:To evaluate the clinical value of dynamic enhanced multi-slice spiral computed tomography(MSCT) in solitary pulmonary nodules(SPN). Methods:40 SPN(25 malignant nodules, 8 inflammatory nodules, and 7 benign nodules) were scanned firstly to determine the nodules range and then scanned through the center of them after contrast media were performed with 5 ml/s or 3 ml/s. The pre-and post-contrast density, peak height after enhanced(PH) and peak time(PT) of SPN were recorded. Results: Moderate enhancement appeared mostly in lung carcinoma and the increased CT density varied from 20 to 60 Hu in 20/25 cases(80%). Peak height of lung cancer was(31.31 ± 10.62)Hu, peak time was 45 s, and the time-density curve represent slowly uptrend. Marked enhancement appeared mostly in inflammatory nodules,and the increased CT density was morn than 40 Hu. Peak height of inflammatory nodules was(49.25 ± 12.44)Hu, and peak time was 80 and 140 s. The curve’s trend of enhancement was wavy. Conclusion:Dynamic contrast enhanced CT can reflect the hemodynamic characteristic of SPN and be used non-invasively in the evaluation of solitary pulmonary nodules.