Objective:To investigate the potential association between the polymorphisms in MIF-173 genotypes and prognosis factors(PSA value,Gleason score and clinical stage) of prostate cancer(PCa). Methods:The polymorphisms of MIF-173 sites were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique using genomic DNA isolated from peripheral blood. The association between the prognosis factors(PSA value,Gleason score and clinical stage) of PCa and different genotypes was evaluated. Results:The MIF-173*C variant allele was associated with higher PSA value of the PCa(adjusted OR =4.39,95%CI:2.43-7.93). It was noted that the MIF-173*C variant allele was associated with higher Gleason score and later clinical stage of PCa patients(adjusted OR = 10.73,95%CI:5.36-21.50[adjusted OR = 15.68,95%CI:7.40-33.23,respectively). Conclusion:The results demonstrated that the MIF-173 G to C variant influenced the PSA value,Gleason soccer and clinical stage of PCa. The MIF-173 G to C variant might have a joint effect on the risk of worse prognosis of PCa.