Mitochondrial dysfunction and changes of energy metabolism in kainite acid-induced epilepsy in rat
DOI:
CSTR:
Author:
Affiliation:

Clc Number:

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    Objective:To study the effect of mitochondrial dysfunction on hippocampal cell apoptosis in kainite acid-induced epilepsy in rat. Methods:Kainite acid-induced epilepsy model was induced by injection of kainite acid into the hippocampus. Forty SD rats were randomly divided into five groups: the control and KA group(6 h,1 d,3 d,7 d),n = 8 for each group. The concentration of free calcium ion,ATP,and ADP,mitochondrial membrane potential,the activities of the mitochondrial respiratory chains complexⅡand Ⅳ,Na+-K+-ATPase in hippocampus were detected. Results:In the hippocampus,the concentration of free calcium ion was increased significantly,and mitochondrial membrane potential,the activities of the mitochondrial respiratory chains complexⅡand Ⅳ,Na+-K+-ATPase,and the concentration of ATP were significantly decreased in a time-dependent manner. Conclusion:Mitochondrial dysfunction may cause hippocampal cell apoptosis in kainite acid-induced epilepsy in rat.

    Reference
    Related
    Cited by
Get Citation

肖 岳,郑 帼,卢孝鹏,张爱华,吴春风.海人酸癫疒大鼠海马存在能量代谢异常和线粒体功能障碍[J].南京医科大学学报(自然科学版英文版),2008,28(11):1468-1470.

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:May 29,2008
  • Revised:
  • Adopted:
  • Online:
  • Published:
Article QR Code