Objective:To compare the efficacy,toxicity and safety of paclitaxel-based or oxaliplatin-based regimens in the treatment of patients with advanced gastric cancer. Methods:Eighty-four patients with advanced gastric cancinoma were divided into 2 groups. Forty-four patients enrolled in group A were given paclitaxel-cisplatin-fluorouracil triplet regimen and 40 patients in group B received oxaliplatin-fluorouracil couplet regimen. Each patient received chemotherapy for at least 2 cycles and was evaluated every 2 cycles. Results:Objective results in the Group A showed:ORR 50%,DCR 84.1%, mTTP 7.0 months,mOS 11.2 months,one-year survival 34.2% and in Group B were:ORR 50%,DCR 75%,mTTP 6.5 months,mOS 10.8 months,one-year survival 33.6%. There was no significant difference in ORR,DCR,mTTP,mOS and 1-year survival(P > 0.05) between two groups. The main toxicity in group A was bone marrow depression and alopecia. The main toxicity in group B was neurotoxicity. Conclusion:Both paclitaxel-based regimen and oxaliplatin-based regimen showed comparable and good efficacy in the treatment of advanced gastric cancinomas. The toxicities caused by the two regimens were mild and tolerable,respectively.