Objective:To study relationship between anxiety,depression and quality of life in patients with functional dyspepsia(FD). Methods:Total of 78 patients with FD(according to Rome Ⅲ criteria)were evaluated by Zung’s self-rating anxiety scales(SAS)and Zung’s self-rating depression scales(SDS) and Chinese version of the MOS 36-item short form healthy survey(SF-36). Results:The SDS and SAS scores were significantly higher in FD patients than those in Chinese normal. The SF-36 scores in all dimensions including physical functioning,role of physical,pain,vitality,role of emotional,mental health,social functioning and general health in FD patients were significantly lower than that in Chinese normal. The SF-36 scores in all dimensions had a negative association with SDS and SAS scores(P < 0.01). Conclusion:There was close relationship between anxiety,depression state and quality of life in FD patients.