Objective:To explore the association of XRCC1 gene single nucleotide polymorphisms and the risk of cervical cancer. Methods:In a hospital-based case-control study of 436 patients with newly diagnosed cervical carcinoma and 503 cancer-free controls frequency-matched by age(± 5 years), we genotyped the -77T>C and Arg399Glu polymorphisms of XRCC1 gene by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method. We further analyzed the interaction of age, menarche age, and parity. Results:We found that the -77T>C variant genotypes were associated with significantly decreased risk of cervical cancer adjusted odds ratio(OR) = 0.64; 95% confidence interval(CI)=0.48~0.86, compared with the wild-type homozygote. Moreover, individuals with 3~4 risk alleles increased the risk of cervical cancer accompanied with older age( > 50 years)(OR=1.64, 95%CI=1.02~2.64) and parity(OR=1.66,95%CI=1.01~2.72). By contrast, no significant association was observed between the Arg399Gln polymorphism and cervical cancer risk. Conclusion:Our finding indicated that the XRCC1-77 CC/CT genotype was significantly associated with a decreased risk of cervical cancer in Jiangsu population.