The Effect of glucocorticoid on the expression of 11beta-hydroxysteroid dehydrogenase in the artery endothelial cells
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    Abstract:

    Objective:To investigate the effect of glucocorticoid on the expression of 11β-hydroxysteroid dehydrogenase in the pig iliac artery endothelial cell(PIEC) under hyperglycemia expression. Methods:PIEC were incubated at a different concentration of glucocorticoid under hyperglycemia(30 mmol/L),the expression of 11β-HSD1,11β-HSD2 were measured by RT-PCR technique, the protain expression of 11β-HSD1,11β-HSD2 were measured by Western-blot technique. Results:Under hyperglycemia, glucocorticoid can upregulate the expression of 11β-HSD1 mRNA and protein(P < 0.05) compared with the control group,and increased with the concertration of cortisone. The expression of 11β-HSD2 mRNA and protein had not change with the concentration of cortisol. Conclusion: High glucose and glucocorticoid can increase the expression of 11β-HSD1 mRNA and protein.

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张 鹏,王继荣,李慧敏,鲁一兵,蒋秀琴,缪 珩.糖皮质激素对动脉内皮细胞11β-羟基类固醇脱氢酶基因表达的影响[J].南京医科大学学报(自然科学版英文版),2009,29(1):32-35.

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  • Received:March 30,2007
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