Objective:To establish a three-dimensional finite element model for orthodontic anchorage micro-implant, and investigate the influence of different titled angles and loadings on the biomechanical characteristics of orthodontic anchorage implant-bone interface. Methods:CAD software and finite element analysis software were used to perform the finite element modeling of the micro-implant with 4 different titled angles, including 30°,45°,60° and 90°. A simulated orthodontic force, which was 0.98N(100 grams),1.96 N(200 grams),2.94 N(300 grams) and 3.92 N(400 grams) separately, was loaded mesiodistally to the mathematical models. The distributions of stress and displacement on the implant-bone interface were analyzed. Results:The neck of micro-implant was the stress concentration zone. As the titled angle and loading increased, the Von-Mises stress and displacement increased. The maximum Von-Mises stress value was 19.263 MPa and the maximum displacement value was 1.2344 μm when the implant was loaded 3.92 N(400 grams) mesiodistally in 90° angle. Conclusion:The micro-implant can be safely loaded with 3.92 N (400 grams) of mesiodistal orthodontic force under 90°angle. The decrease of the titled angle can efficaciously enhance the ability, implicating that the implant can bear a mesiodistal orthodontic force, and titled angle should be choose when the micro-implant is embedded.