Objective:To study the significance of variance in plasma adiponectin(APN) in hypertensive patients with arrhythmia, and the relationship between plasma APN and brain natriuretic peptide(BNP), c-reactive protein(CRP). Methods:The study comprised 71 hypertensive subjects who were divided into 2 groups, 35 of whom were hypertension with arrhythmia, the other were simplex hypertensive subjects. The plasma APN, BNP and CRP were determined. The relationship between them were tested. Results: Plasma APN levels significantly decreased in both hypertension with arrhythmia group[(0.977 ± 0.340)mg/L] and simplex hypertensive subjects[(1.977 ± 0.990)mg/L] than that in control[(6.451 ± 1.972)mg/L]. APN levels in hypertension with arrhythmia group significantly decreased than that in simplex hypertensive subjects. Whereas plasma BNP and CRP levels significantly increased in both hypertension with arrhythmia group and simplex hypertensive subjects. BNP and CRP levels in hypertension with arrhythmia group significantly decreased than that in simplex hypertensive subjects. In both hypertension with arrhythmia group and simplex hypertensive subjects, plasma adiponectin levels negatively correlated with BNP and CRP. Conclusion:Plasma adiponectin decreased in simplex hypertensive subjects and BNP and CRP increased. The change was more significantly in hypertension with arrhythmia group. Plasma adiponectin negatively associated with BNP and CRP. Adiponectin may be related to the occurrence and development of hypentension.