Objective:To investigate the effect and mechanism of the intestinal ischemic preconditioning on hepatic ischemia-reperfusion injury in rats. Methods:Thirty SD rats were divided into three groups randomly:sham-operated group(Sham group), ischemia-reperfusion group(IR group:produced by total inflow occlusion for 30 min),and remote ischemic preconditioning group(RIPC group:induced with superior mesenteric artery occlusion before HIRI by 10 min ischemia and 10 min reperfusion). Markers of liver and intesine injury and TNF-α,ICAM-1 in liver were measured after reperfusion for 120 min. Results:IR group was associated with increased serum aminotransferases(ALT,AST), MPO activity endotoxin and the pathological injury scores. Meanwhile,in liver tissue TNF-α and ICAM-1 expression were high when IR only. There was significant improvement in these variables in RIPC group. Conclusion:RIPC of the intestine reduced HIRI which may depend on the decrease of pro-inflammatory and activity of neutrophils.